MICROBIAL WEAPONS

Toxins are classified as exotoxins or endotoxins as the (WEAPONS OF THE CRIMINALS) –

• alpha,beta,gamma,delta and epsilon toxin
• botulinum toxin

if our anatomyland cells are naked or nude they look like a dry covering

TOXINS Toxins are classified as exotoxins or endotoxins as the (WEAPONS OF THE CRIMINALS) –

shiga like toxin or verocytotoxin (VT OR SLT) Verocytotoxin is a Shiga-like toxin produced by the E. coli strain O157, and Shigella type 1.

It causes acute renal failure in children, as a result ofHaemolytic uraemic syndrome.

The toxin has two parts. The A part damages gutepithelium through inhibiting its protein synthesis, facilitating entry to the blood stream. The 5 B parts are adapted to inserting the A part into epithelial cells.

cytolytic toxin tracheal cytotoxin - produced by bordetella pertusis

Anthrax toxin is composed of a cell-binding protein, known as protective antigen (PA), and two enzyme components, called edema factor (EF) and lethal factor (LF). These three protein components act together to impart their physiological effects. It acts as the trojan horse carrying both lethal factor and oedema factor. Diphtheria toxin is an exotoxinsecreted by Corynebacterium diphtheriae, the pathogenicbacterium that causes diphtheria. Unusually, the toxin gene is encoded by a bacteriophage (avirus that infects bacteria).[1] Thetoxin causes the disease diphtheria in humans by gaining entry into the cell cytoplasm and inhibiting protein synthesis.

• ALL BLOOD CELLS COVERED (helps in killing police and disrupting the environment of blood)
• coagulase - platelets
• agglutinogens -
• clumping factor - the fundamental unit of clotting,before conversion it is in form of fibrinogen,this factor binds to fibrinogen.
• staphylokinase(fibrinolysin) - after the clot is formed it is mainly made of fibrin but this enzyme breaks the clots and makes this process all over again.
• leuococidin - leucocytes - polymorphonuclear leucocytes and macrophages gets killed
• hemolytic toxin or called hemolysin (-toxins ending with lysin) - rbc cells
• streptolysin - Streptolysin O and streptolysin S
• tetanolysin
• pneumolysin
• erythrogenic or pyrogenic extoxin
• alpha,beta,gamma,delta and epsilon toxin -

• GIT CELLS (helps in killing git cells)
• enterotoxin - causes food poisoning,this is where the food trucks gets infected inside the food mill a kind of adulteration.
• emetic toxin
• enterotoxins (LT,VT(SLT),ST)
• VT1 ,VT2

SKIN (helps bacteria in breaking or to breach skin border) exfoliative or epidermolytic toxin

• NERVOUS SYSTEM (break the communication system by hacking their telephone communication wires)
• neurotoxin
• Tetanospasmin - produces tetanus (lock jaw)
• botulinum toxin

• OTHER TOXINS - protein antigens
• A- protein - interacts with the dogs (igG type of antibodies ,it binds to fc region-constant region)
• M - Protein
• R - protein
• T - Protein

carbohydrate antigens -

• acids -
• lipoteichoic acid
• teichoic acid - adherence to mucosal surface (provides the ground for attaching and standing)
• hyaluronic acid
• hyaluronic acid capsule

• Edema factor /factor 1
• lethal factor /factor 3 - death causer
• protective antigen /factor 2 -

peptidoglycan - inhibits inflammtory response (inhbits the first signs of invasion)

• The structural recognizers or antigens (this may be harmful because it helps the bacteria to move and gives protection)
• O - somatic antigen - (LPS)- endotoxic inhibits phagocytosis
• K- antigen - protects from phagocytosis
• Fimbriae - mannose resistant
• colonizing factor antigens - found in ETEC
• P - Fimbriae is found in uropathogenic E.Coli

• toxic shock syndrome toxin
• pertusis toxin
• Pyrogenic exotoxin

weapons acting at the subcellular level

• proteases - destroy or break proteins
• lipases - destroy or break lipids
• lipoproteinases - serum opacity factor - breaks both lipids and proteins
• phospholipase (cell wall phospholipids) - break down .
• deoxyribonuclease - Destroy or break DNA